精神障害

精神障害は多くの人々に影響を及ぼし、非常に幅広い病態を包含します。 障害の程度は、社会性が薄弱になる軽度なものから人命を脅かすものまで幅広い範囲があります。イオンチャネルがこれらの疾患において重要な役割を果たすという証拠が増えてきています。神経の興奮性、神経伝達物質の放出、遺伝子転写および脳可塑性は、イオンチャネルの機能性に依存し、それゆえイオンチャネルの機能不全によって害される可能性があります。

 

精神障害に関与するイオンチャネル：

 

Key ion channels

Nav1.1, 1.2 & 1.3
Cav1.2
Kv1.1, 7.3 & 11.1
Kir3.1 & 4.1
KCa1.1 & 3.1
TASK3
GABA


Nav1.1, 1.2 and 1.3

Posters

  • 詳細 Multi-parameter ion channel screening: mechanism-of-action data directly from HTS
    Year: 2019 First author: Kammonen et Al., 2019
  • 詳細 Biophysical and pharmacological characterization of multiple Nav subtypes on Qube
    Year: 2016 First author: Lindqvist et Al
  • 詳細 Biophysical and pharmacological profiling of multiple Nav subtypes on QPatch HT
    Year: 2016 First author: Lindqvist et al., 2016
  • 詳細 Exploring stem cell-derived cardiomyocytes with automated patch clamp techniques
    Year: 2012 First author: Schrøder et al., 2012
  • 詳細 Data quality is not affected by cell suspension density
    Year: 2006 First author: Mathes et al., 2006
  • 詳細 Evaluation of throughput and data quality
    Year: 2009 First author: Olsen et al., 2009
  • 詳細 Pharmacological characterization of voltage- and ligand-gated ion channels
    Year: 2006 First author: Olsen et al., 2006

Papers

  • 詳細 The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/− mice
    Year: 2017
  • 詳細 Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels
    Year: 2009 First author: Korsgaard et al., 2009
  • 詳細 Stable response for ligand and voltage-gated ion channels on QPatch
    Year: 2010 First author: Olsen et al., 2010
  • 詳細 QPatch: the missing link between HTS and ion channel drug discovery.
    Year: 2009 First author: Mathes
  • 詳細 Automated Patch Clamping Using the QPatch
    Year: 2009 First author: Jones et al. 2009
  • 詳細 A small molecule activator of Nav1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo
    Year: 2017 First author: K Frederiksen

Reports

  • 詳細 Voltage-gated sodium channels on QPatch 16
    Year: 2012 First author: Olsen 2012
  • Nav1.1 currents on Qube
    Year: 2018 First author: Klint et Al.
  • 詳細 Electrophysiological characterization of human iPSC-derived motor neurons using Qube 384 and QPatch
    Year: 2019 First author: Rosholm et Al.

Cav1.2

Posters

  • 詳細 Qube as a tool for assay optimization of CiPA cells and protocols by using multiple IC, EC solutions and hERG, Nav1.5 and Cav1.2 on the same QChip
    Year: 2016 First author: Schupp et al., 2016
  • 詳細 Exploring stem cell-derived cardiomyocytes with automated patch clamp techniques
    Year: 2012 First author: Schrøder et al., 2012

Papers

  • 詳細 A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment
    Year: 2015 First author: Mistry et al., 2015
  • 詳細 Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator
    Year: 2015 First author: Okada et al., 2015
  • 詳細 MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes
    Year: 2013 First author: Kramer et al., 2013

Reports

  • 詳細 hCav1.2 recordings on Qube 384 using step, train and CiPA protocols
    Year: 2018 First author: Schupp
  • 詳細 CHO Cav1.2 on QPatch (ChanTest)
    Year: 2011 First author: Friis et al., 2011
  • 詳細 Cav1.2 on Qube 384
    Year: 2017 First author: Schupp, M
  • 詳細 Cor.At cells embryonic stem cell derived cardiomyocytes on QPatch
    Year: 2009 First author: Schrøder et al., 2009

Kv1.1, Kv2.1, 7.3 and 11.1

Posters

  • 詳細 Enhancing throughput with multiple cell lines per well
    First author: Olsen et al., 2006
  • 詳細 Strategies for enhancing throughput in ion channel drug screening
    Year: 2008 First author: Jacobsen et al., 2008
  • 詳細 Pharmacological characterization of voltage- and ligand-gated ion channels
    Year: 2006 First author: Olsen et al., 2006
  • 詳細 Qube as a tool for assay optimization of CiPA cells and protocols by using multiple IC, EC solutions and hERG, Nav1.5 and Cav1.2 on the same QChip
    Year: 2016 First author: Schupp et al., 2016
  • 詳細 Characterization of hERG blockers using the automated QPatch 16 screening system
    Year: 2005 First author: Jacobsen et al., 2005
  • 詳細 Data quality is not affected by cell suspension density
    Year: 2006 First author: Mathes et al., 2006
  • 詳細 “Clip Detecting” with series resistance compensation using an automated patch clamp system
    Year: 2012 First author: Løjkner et al., 2012
  • A dipolar cycloaddition reaction to access 6-methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines enables the discovery synthesis and preclinical profiling of a P2X7 antagonist clinical candidate
    Year: 2017 First author: Chrovian et Al.

Papers

  • 詳細 Arrangement of Kv1 α subunits dictates sensitivity to tetraethylammonium
    Year: 2010 First author: Al-Sabi et Al
  • 詳細 Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels
    Year: 2014 First author: Daly et al., 2014
  • 詳細 MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes
    Year: 2013 First author: Kramer et al., 2013
  • 詳細 Characterization of Potassium Channel Modulators with QPatch™ Automated Patch-Clamp Technology: System Characteristics and Performance To cite this article:
    Year: 2004 First author: Kutchinsky et al., 2004
  • 詳細 Automated Patch Clamping Using the QPatch
    Year: 2009 First author: Jones et al. 2009
  • 詳細 Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels
    Year: 2009 First author: Korsgaard et al., 2009
  • 詳細 Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors
    Year: 2017 First author: Huang
  • 詳細 QPatch: the missing link between HTS and ion channel drug discovery.
    Year: 2009 First author: Mathes
  • 詳細 A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment
    Year: 2015 First author: Mistry et al., 2015
  • 詳細 Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator
    Year: 2015 First author: Okada et al., 2015

Reports

  • 詳細 Reliable Kv2.1 assasy and pharmacology on the QPatch
    Year: 2017 First author: Schupp et Al.
  • 詳細 CHO-hERG Duo characterization and functional validation on QPatch
    Year: 2011 First author: Jacobsen et al., 2011
  • 詳細 CHO-hERG Duo in multi-hole mode on QPatch
    Year: 2011 First author: Jacobsen et al., 2011
  • 詳細 Stable response for ligand and voltage-gated ion channels on QPatch
    Year: 2010 First author: Olsen et al., 2010

Kir

Reports

  • 詳細 HEK-hKir2.1 on QPatch
    Year: 2013 First author: Olsen et al., 2013

Kca1.1 & 3.1

Papers

  • 詳細 Development of a QPatch Automated Electrophysiology Assay for Identifying KCa3.1 Inhibitors and Activators
    Year: 2013 First author: Jenkins et al., 2013
  • 詳細 New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1
    Year: 2014 First author: Coleman et al., 2014
  • 詳細 Inhibition of the potassium channel KCa3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury
    Year: 2016 First author: Staala et al., 2016

Reports

  • 詳細 The intermediate conductance Ca2+ – activated K+ channel on Qube 384
    Year: 2017 First author: Sauter
  • 詳細 HEK293-KCa on QPatch
    Year: 2008 First author: Jacobsen et al., 2008

GABA

Posters

  • 詳細 Development and validation of ligand-gated ion channel assays using the Qube 384 automated electrophysiology platform
    Year: 2019 First author: Marklew et Al., 2019
  • 詳細 Pharmacological evaluation of GABAA receptor subtypes on Qube 384
    Year: 2019 First author: Boddum et Al. 2019
  • 詳細 Ligand-activation of GABAA receptors on the automated patch clamp platforms QPatch and Qube 384 using conventional electrophysiology and optopharmacology
    Year: 2018 First author: Schupp et Al., 2018
  • 詳細 Application of QPatch 16 for drug screening of ligand-gated ion channels
    Year: 2005 First author: Andersen et al., 2005
  • 詳細 Assessing functional properties of ligand-gated ion channels with automated whole-cell patch clamp technology
    Year: 2006 First author: Olsen et al., 2006

Reports

  • 詳細 Pharmacological evaluation of GABAA receptor subtypes on Qube 384
    Year: 2019 First author: Boddum et Al. 2019

Stem cells

Posters

  • 詳細 Characterization of hiPSC-derived neurological disease models using automated patch clamp (Qube and QPatch)
    Year: 2019 First author: Rosholm et Al.
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