2019年第一四半期の新しい論文やポスター、レポートを紹介
ソフィオンのパッチクランプを使い、ALS疾患モデルにおいてiPS細胞由来の運動ニューロンがどのように特性化するのか学びましょう。ソフィオンのQubeや、癌領域のイオンチャネルについて、Amgen、Axxam、 Sanofi、 Kings College London、 BrainXell などのアカデミアや研究機関から学びましょう。
学術論文
D Wang et al 2018. Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers. Mar. Drugs, 16(12), 475
B Kaproń et al 2018. Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies. European Journal of Pharmaceutical Sciences Vol 129, Pages 42-57
S Yadav et al 2018. Benzothiophenes as Potent Analgesics Against Neuropathic Pain. Biochemical and Biophysical Roles of Cell Surface Molecules, Advances in Experimental Medicine and Biology 1112
Reyes-Corral et al 2019. Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines. The Journal of Pharmacology and Experimental Therapeutics [17 Jan 2019, 369(1):152-162]
Miner et al 2019. Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways. Frontiers in Pharmacology, Vol 10, Article 51
Das et al 2019. Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis. Nature Scientific Reports, Vol 9, Article 2904
Sanson et al 2019. Electrophysiological and Pharmacological Characterization of Human Inwardly Rectifying Kir2.1 Channels on an Automated Patch-Clamp Platform. Assay Drug Dev Technol. 2019 Mar
Bagchi et al 2019. Disruption of Myelin Leads to Ectopic Expression of KV1.1 Channels with Abnormal Conductivity of Optic Nerve Axons in a Cuprizone-Induced Model of Demyelination
ポスター:
Sauter et al 2019. Biophysical and Pharmacological Profiling of Multiple Voltage-Gated Sodium Channel Subtypes on QPatch II. Poster, Biophysics 2019
Rosholm & Schupp 2019. iPSC-Derived Motor Neurons on the Automated Patch Clamp Platforms Qube and QPatch. Poster, Biophysics 2019
Boddum et al 2019. Optical modulation of ion channels using Qube Opto. Poster, Mammalian Sensory Systems 2019
アプリケーションレポート:
Boddum, Korsgaard 2019. Pharmacological evaluation of GABAA receptor subtypes on Qube 384. Sophion Application Report