Qube用カレントクランプモジュール
Qube can also carry out current clamp experiments. All 384 sites can switch between voltage clamp and current clamp in the same protocol. And multiple protocols can be combined so even including a ligand gated recording is possible in the same experiment.
- Voltage- and current clamp can be combined in the same protocol
- Possible to include up to 500 segments protocol
- Segments can be as short as 1 ms
- User-defined sampling rate up to 50 kHz
Current clamp execution in 384 format together with powerful analysis in Sophion Analyzer enables:
- Screening of compound libraries on ion channel targets
- Obtaining enough statistically relevant data on varying parameters such as current clamp readout
- Elucidation of compound effect on behavior in cells with more ion channels in concert such as cardiomyocytes or neurons
Cardiomyocytes can be monitored in current clamp for the effect of pharmacology on the width of the action potentials
You can read more about Sophion Current Clamp here