QPatch/Qube 384を用いた20報の論文が2021年第4四半期に発表されました

QPatchおよびQube 384を用いた論文はsophion.com内 Publicationよりいつでも確認することができます。

Labau, et al. (2021). Lacosamide Inhibition of Nav1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore. Frontiers in Pharmacology, 12(December), 1–17.

Bennett, et al. (2021). Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties. JCI Insight.

Adams et al. (2021). Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav 1.7 for the Treatment of Pain. Journal of Medicinal Chemistry.

Grillo et al. (2021). Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems. European Journal of Medicinal Chemistry, 183.

Tran et al. (2021). Evaluation of Efficient Non-reducing Enzymatic and Chemical Ligation Strategies for Complex Disulfide-Rich Peptides. Bioconjugate Chemistry, 32(11), 2407–2419.

Voronkov et al. (2022). Modifying naloxone to reverse fentanyl-induced overdose. International Journal of Pharmaceutics, 611(November 2021), 121326.

Sang et al. (2021). Synthesis and bioevaluation of diaryl urea derivatives as potential antitumor agents for the treatment of human colorectal cancer. European Journal of Medicinal Chemistry, 229, 114055.

Li et al. (2022). Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity. European Journal of Medicinal Chemistry, 228, 114036.

Zhang et al. (2021). Discovery of quinazolinyl-containing benzamides derivatives as novel HDAC1 inhibitors with in vitro and in vivo antitumor activities. Bioorganic Chemistry, 117(September), 105407.

Wilson et al. (2021). Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target. Journal of Medicinal Chemistry.

Kilfoil et al. (2021). Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters. European Journal of Pharmacology, 912(October), 174584.

Pasquarelli, A. (2021). Proteome and Membrane Channels.

Mori et al. (2022). Corticotropin releasing hormone receptor 2 antagonist, RQ-00490721, for the prevention of pressure overload-induced cardiac dysfunction. Biomedicine & Pharmacotherapy, 146(September 2021), 112566.

Virginio et al. (2021). Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay. SLAS Discovery

Di Donato et al. (2021). Therapeutic potential of TRPM8 antagonists in prostate cancer. Scientific Reports, 11(1), 1–16.

Mowbray et al. (2021). DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis. Journal of Medicinal Chemistry, 64(21), 16159–16176.

Schwalen et al. (2021). Scalable Biosynthetic Production of Knotted Peptides Enables ADME and Thermodynamic Folding Studies. ACS Omega, 6(44), 29555–29566.

Dashevsky et al. (2021). Novel Neurotoxic Activity in Calliophis intestinalis Venom. Neurotoxicity Research.

Dongol et al. (2021). Voltage-Gated Sodium Channel Modulation by a New Spider Toxin Ssp1a Isolated From an Australian Theraphosid. Frontiers in Pharmacology, 12(December).

Ballet et al. (2022). In vitro ion channel profile and ex vivo cardiac electrophysiology properties of the R(-) and S(+) enantiomers of hydroxychloroquine. European Journal of Pharmacology, 915(September 2021), 174670.

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