2019年第4四半期に発表された論文・ポスター・レポート一覧
個別化医療,がん関連イオンチャネル研究におけるオートパッチクランプ装置の有用性を示した論文,また新機能 ‘Adaptive Protocols’ についてのレポートが発行されました.これら論文の著者は以下の研究機関や製薬企業に所属されています: Aptuit, Icagen, Charles River, BeiGene, Chugai Pharmaceutical, UC Davis, Nanyang University, University of Queensland など．
Papers
Ashmore et Al., 2019 Wnts control membrane potential in mammalian cancer cells. The Journal of Physiology, Volume 597, Issue24
Ong et Al., 2019. Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment. Bioelectricity Vol. 1, No. 3.
Grillo et Al., 2019. Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems. European Journal of Medicinal Chemistry. Volume 183, 1 December.
Wu et Al., 2019. Synthesis and Biological Evaluation of Five‐Atom‐Linker‐Based Arylpiperazine Derivatives with an Atypical Antipsychotic Profile. ChemMedChem 2019, 14, 2042–2051.
Billakota et Al., 2019. Personalized medicine: Vinpocetine to reverse effects of GABRB3 mutation. Epilepsia 2019;60:2459–2465.
Zhu et Al., 2019. Structural optimization of aminopyrimidine-based CXCR4 antagonists. European Journal of Medicinal Chemistry, Volume 187, 1 February 2020, 111914
Chow et Al., 2019. Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel NaV1.1 Provide Novel Leads for Development of Antiepileptic Drugs. Pharmacol. Transl. Sci. 2019.
Hue et Al., 2019. Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel NaV1.7 Inhibition. Bioconjugate Chem. 2020, 31, 1, 64-73
Liu, Li and Chen 2019. Role of High-Throughput Electrophysiology in Drug Discovery. Current Protocols in Pharmacology, 87, e69. doi: 10.1002/cpph.69. REVIEW.
Isobe et Al., 2019. Cardiac safety assessment with motion field imaging analysis of human iPS cell-derived cardiomyocytes is improved by an integrated evaluation with cardiac ion channel profiling. J Toxicol Sci. 2019;44(12):859-870
Werner et Al. 2019. Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile. J. Med. Chem. 2019, 62, 24, 11194-11217
Posters
Braksator et Al., 2019. Validation of B’SYS KV3.x cell lines using automated and manual patch-clamp electrophysiology. Ion Channel Modulation Symposium, Boston MA, 2019
Application Reports
Schupp 2019. Stable Vhalf values and reliable potentiation of Kv7.3/7.2 currents on Qube 384
Rosholm 2019. Electrophysiological characterization of human iPSC-derived motor neurons using Qube 384 and QPatch