2020年第1四半期以降に出版された査読つき論文

TRPV1、NaV1.7、オートパッチクランププラットフォーム間でのデータばらつき比較、TMEM16Aと嚢胞性線維症についての論文が2020年第1四半期以降に出版されました。著者には学術研究機関、製薬企業CiPAコンソーシアム、AbbVie社、Genentech社、クイーンズランド大学、Enterprise Therapeutics社など多くの方々が含まれています。

Agwa, A. J. et Al. Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. J. Biol. Chem. 295, 5067–5080 (2020).

Choi, R. et Al. Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned. Int. J. Parasitol. (2020) doi:https://doi.org/10.1016/j.ijpara.2020.01.006.

Damann, N. et Al. In vitro characterization of the thermoneutral transient receptor potential vanilloid-1 (TRPV1) inhibitor GRTE16523. Eur. J. Pharmacol. 871, 172934 (2020).

Danahay, H. L. et Al. TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis. Am. J. Respir. Crit. Care Med. 201, 946–954 (2020).

Jalily, P. H. et Al. Put a cork in it: Plugging the M2 viral ion channel to sink influenza. Antiviral Res. 178, 104780 (2020).

Katavolos, P. et Al. Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs. Toxicol. Pathol. 48, 465–480 (2020).

Kramer, J. et Al. Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells. Sci. Rep. 10, 1–15 (2020).

Mueller, A. et Al. Mapping the Molecular Surface of the Analgesic Na V 1.7-Selective Peptide Pn3a Reveals Residues Essential for Membrane and Channel Interactions. ACS Pharmacol. Transl. Sci. (2020) doi:10.1021/acsptsci.0c00002.

Ridder et Al. (2020) “A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm”, Toxicology and Applied Pharmacology, Volume 395, 15 May 2020