QPatch/Qube 384を用いた10報の論文が2021年第3四半期に発表されました

今四半期においては特に、顧みられない熱帯病治療薬の分野で多くの論文が出版されました。蛇毒を中和する抗体の基礎研究から、マラリア、住血吸虫症、クリプトスポリジウム症の薬剤開発に至るまで、すべて QPatch の研究によって推進されています。

慢性疼痛、がん、喘息や嚢胞性線維症などの呼吸器疾患に関する理解は、Qube や QPatch を使用する大学や企業の研究機関によって、さらに深まりました。

Ledsgaard et al., 2021 In vitro discovery and optimization of a human monoclonal antibody that neutralizes neurotoxicity and lethality of cobra snake venom. BioRxiv, 2021.09.07.459075.

Hamilton et al., 2021 Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme. Journal of Medicinal Chemistry64(15), 11302–11329.

Mambwe et al., 2021 Structure-Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum in Vitro. ACS Medicinal Chemistry Letters12(8), 1333–1341

Hao et al., 2021 Emerging Modulators of TMEM16A and Their Therapeutic Potential. Journal of Membrane Biology, 254(4), 353–365

Roecker et al., 2021 Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile. ACS Medicinal Chemistry Letters12(6), 1038–1049.

Gardner et al., 2021 The discovery of a novel series of compounds with single-dose efficacy against juvenile and adult Schistosoma species. PLoS Neglected Tropical Diseases15(7), 1–21.

Danziger et al., 2021 Nav1.7 target modulation and efficacy can be measured in nonhuman primate assays. Science Translational Medicine13(594), 1–14.

Oboh et al., 2021 Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin. Journal of Medicinal Chemistry64(15), 11729–11745.

Shackleford et al., 2021 Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials. Journal of Medicinal Chemistry64(17), 12582–12602.

Feng et al., 2021 N -Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors. ACS Medicinal Chemistry Letters12(10), 1546–1552.