Use of automated patch clamp in cardiac safety assessment: past, present and future perspectives
Contact
10.05.2021
Translational Studies on Anti-Atrial Fibrillatory Action of Oseltamivir by its in vivo and in vitro Electropharmacological Analyses
Contact
10.05.2021
A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome
Contact
10.05.2021
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19
Contact
10.05.2021
Cardiotoxic Potential of Hydroxychloroquine, Chloroquine and Azithromycin in Adult Human Primary Cardiomyocytes
Contact
10.05.2021
Chemical modulation of Kv7 potassium channels
Contact
10.05.2021
Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID‐19: A simulation study
Contact
10.05.2021
Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach
Contact
10.05.2021
Isoliquiritigenin, an active ingredient of Glycyrrhiza, elicits antinociceptive effects via inhibition of Nav channels
Contact
10.05.2021
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth
Contact
10.05.2021
Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain
Contact
10.05.2021
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase
Contact
23.09.2019
Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain
Contact
23.09.2019
Disruption of Myelin Leads to Ectopic Expression of KV1.1 Channels with Abnormal Conductivity of Optic Nerve Axons in a Cuprizone-Induced Model of Demyelination
Contact
23.09.2019
Development of a high-throughput fluorescent no-wash sodium influx assay
Contact
23.09.2019
From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei.
Contact
23.09.2019
Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform
Contact
25.04.2019
Disruption of Myelin Leads to Ectopic Expression of KV1.1 Channels with Abnormal Conductivity of Optic Nerve Axons in a Cuprizone-Induced Model of Demyelination
Contact
25.04.2019
Electrophysiological and Pharmacological Characterization of Human Inwardly Rectifying Kir2.1 Channels on an Automated Patch-Clamp Platform
Contact
25.04.2019
Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis
Contact
25.04.2019
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that Fully Bronchodilate Airway
Contact
25.04.2019
Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines
Contact
25.04.2019
Benzothiophenes as Potent Analgesics Against Neuropathic Pain
Contact
25.04.2019
Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies
Contact
25.04.2019
Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers
Contact
03.01.2019
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
Contact
03.01.2019
Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain
Contact
03.01.2019
Biological Profiling of Coleoptericins and Coleoptericin-Like Antimicrobial Peptides from the Invasive Harlequin Ladybird Harmonia axyridis
Contact
13.12.2018
Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis
Contact
08.10.2018
Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain
Contact
08.10.2018
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
Contact
19.09.2018
A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family
Contact
30.01.2018
Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis
Contact
13.12.2017
A dipolar cycloaddition reaction to access 6-methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines enables the discovery synthesis and preclinical profiling of a P2X7 antagonist clinical candidate
Contact
11.12.2017
Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells: An In-Vitro Model to Predict Cardiac Effects of Drugs
Contact
09.11.2017
The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/− mice
Contact
09.11.2017
Eleclazine exhibits enhanced selectivity for long QT syndrome type 3–associated late Na+ current
Contact
09.11.2017
Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs
Contact
09.11.2017
Cardiac sodium channel antagonism – Translation of preclinical in vitro assays to clinical QRS prolongation
Contact
07.11.2017
Discovery and electrophysiological characterization of SKF-32802; a novel hERG agonist found through a large-scale structural similarity search
Contact
27.09.2017
Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels
Contact
27.09.2017
Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3′,2’:3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5′-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes
Contact
27.09.2017
Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi
Contact
27.09.2017
Pharmacological screening technologies for venom peptide discovery
Contact
27.09.2017
Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands
Contact
27.09.2017
An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases
Contact
27.09.2017
Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors
Contact
29.06.2017
A small molecule activator of Nav1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo
Contact
02.06.2017
Effect of antiarrhythmic drugs on small conductance calcium – activated potassium channels
Contact
02.05.2017
NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions
Contact
28.04.2017
Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function
Contact
27.04.2017
Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling
Contact
25.04.2017
Automated and manual patch clamp data of human induced pluripotent stem cell-derived dopaminergic neurons
Contact
11.04.2017
Arrangement of Kv1 α subunits dictates sensitivity to tetraethylammonium
Contact
04.04.2017
Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels
Contact
04.04.2017
High throughput physiological screening of iPSC-derived cardiomyocytes for drug development
