Use of automated patch clamp in cardiac safety assessment: past, present and future perspectives
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10.05.2021
Translational Studies on Anti-Atrial Fibrillatory Action of Oseltamivir by its in vivo and in vitro Electropharmacological Analyses
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10.05.2021
A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome
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10.05.2021
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19
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10.05.2021
Cardiotoxic Potential of Hydroxychloroquine, Chloroquine and Azithromycin in Adult Human Primary Cardiomyocytes
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10.05.2021
Chemical modulation of Kv7 potassium channels
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10.05.2021
Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID‐19: A simulation study
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10.05.2021
Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach
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10.05.2021
Isoliquiritigenin, an active ingredient of Glycyrrhiza, elicits antinociceptive effects via inhibition of Nav channels
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10.05.2021
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth
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10.05.2021
Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain
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10.05.2021
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase
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23.09.2019
Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain
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23.09.2019
Disruption of Myelin Leads to Ectopic Expression of KV1.1 Channels with Abnormal Conductivity of Optic Nerve Axons in a Cuprizone-Induced Model of Demyelination
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23.09.2019
Development of a high-throughput fluorescent no-wash sodium influx assay
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23.09.2019
From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei.
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23.09.2019
Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform
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25.04.2019
Disruption of Myelin Leads to Ectopic Expression of KV1.1 Channels with Abnormal Conductivity of Optic Nerve Axons in a Cuprizone-Induced Model of Demyelination
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25.04.2019
Electrophysiological and Pharmacological Characterization of Human Inwardly Rectifying Kir2.1 Channels on an Automated Patch-Clamp Platform
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25.04.2019
Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis
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25.04.2019
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that Fully Bronchodilate Airway
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25.04.2019
Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines
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25.04.2019
Benzothiophenes as Potent Analgesics Against Neuropathic Pain
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25.04.2019
Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies
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25.04.2019
Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers
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03.01.2019
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel
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03.01.2019
Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain
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03.01.2019
Biological Profiling of Coleoptericins and Coleoptericin-Like Antimicrobial Peptides from the Invasive Harlequin Ladybird Harmonia axyridis
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13.12.2018
Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis
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08.10.2018
Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain
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08.10.2018
Inhibitory effects of cannabidiol on voltage-dependent sodium currents
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19.09.2018
A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family
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30.01.2018
Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis
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13.12.2017
A dipolar cycloaddition reaction to access 6-methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines enables the discovery synthesis and preclinical profiling of a P2X7 antagonist clinical candidate
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11.12.2017
Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells: An In-Vitro Model to Predict Cardiac Effects of Drugs
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09.11.2017
The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/− mice
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09.11.2017
Eleclazine exhibits enhanced selectivity for long QT syndrome type 3–associated late Na+ current
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09.11.2017
Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs
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09.11.2017
Cardiac sodium channel antagonism – Translation of preclinical in vitro assays to clinical QRS prolongation
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07.11.2017
Discovery and electrophysiological characterization of SKF-32802; a novel hERG agonist found through a large-scale structural similarity search
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27.09.2017
Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels
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27.09.2017
Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3′,2’:3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5′-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes
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27.09.2017
Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi
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27.09.2017
Pharmacological screening technologies for venom peptide discovery
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27.09.2017
Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands
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27.09.2017
An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases
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27.09.2017
Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors
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29.06.2017
A small molecule activator of Nav1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo
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02.06.2017
Effect of antiarrhythmic drugs on small conductance calcium – activated potassium channels
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02.05.2017
NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions
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28.04.2017
Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function
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27.04.2017
Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling
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25.04.2017
Automated and manual patch clamp data of human induced pluripotent stem cell-derived dopaminergic neurons
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11.04.2017
Arrangement of Kv1 α subunits dictates sensitivity to tetraethylammonium
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04.04.2017
Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels
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04.04.2017
High throughput physiological screening of iPSC-derived cardiomyocytes for drug development