High throughput screening for mode-of-action on Nav1.4

A high-fidelity patch clamp set up is necessary to discover use-dependent mode of action. Qube is a second generation automated patch clamp system that fulfills this requirement and allows for testing of many thousands of compounds per day in an unattended fashion. Using Qube in a drug development cascade allows to ask the right questions during the primary screen, making a follow-up validation study obsolete. Some key points for a Qube screening like this are:

• Giga-ohm seal
• 99% average success rates
• Very tight data
• Discrimination between different modes-of-action

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