Programme
Day one – wednesday
08.00 Registration and tea/coffee
09.00 Welcome remarks
Session 1 – Professor David Wyllie, Edinburgh University
09.15 Professor Matthew Nolan – University College London (UCL)
Diverse computational roles for HCN1 ion channels in behaviour
09.40 Dr Hongjie Yuan – Emory University
GRIN mutations in neurological diseases: from molecular mechanism to rescue pharmacology
10.05 Dr Stephen Brickley – Imperial College London (ICL)
Age-related changes in synaptic transmission during cognitive decline
10.30 Tea/coffee – exhibits and posters
11.15 Professor Hirokazu Hirai – Gunma University Graduate School of Medicine
GABA-B receptor and type 1 metabotropic glutamate receptor (mGluR1) as therapeutic targets for hereditary spinocerebellar ataxia
11.40 Professor Jian Yang – Columbia University
Antiarrhythmic natural compounds and structural basis of modulation of an endolysosomal calcium channel
12.05 Professor Lucia Sivilotti – University College London (UCL)
Agonist efficacy in Cys-loop ion channels: the single molecule view
12.30 Lunch
Session 2 – Professor Derek Bowie – McGill University
14.00 Professor Annette Dolphin – University College London (UCL)
Neuronal calcium channel trafficking and function: relevance to chronic pain
14.25 Professor Yasuo Mori – Kyoto University
Redox biology of TRP channels
14.50 Professor Uwe Rudolph – McLean Hospital and Harvard University
Towards a circuit-based pharmacology of GABAA receptors
15.15 Tea/coffee – exhibits and posters
16.00 Professor Halima Ouadid-Ahidouch – Université de Picardie Jules Verne
KV10.1 potassium channel in breast cancer : role in cancer progression in relation with the tumor microenvironment
16.25 Professor Diane Lipscombe – Brown University
Cell-specific splicing of neural calcium ion channels modulates activity and drug
16.50 Professor Anders Jensen – Copenhagen University
Allosteric modulation of GABA-A receptors
17.15 Wrap-up
17.30 Drinks reception in the Scholar’s Garden
18.30 Dinner in the Great Hall of Clare College
Day two – Thursday
08.00 Tea/Coffee
09.00 Welcome Remarks
Session 3 – Chair Professor Stephen Tucker – Oxford University
09.05 Professor David Beech – Leeds University
Piezo1 channel function and small-molecule modulation
09.30 Professor David Bennett – University of Oxford
The role of NaV1.7 in human pain disorders
09.55 Professor Jun-ichi Okada – University of Tokyo
Cardiac safety assessment of drug effects based on combining automated patch clamp and three-dimensional heart simulator
10.20 Tea/Coffee, Exhibits and Posters
11.20 Professor Bonnie Wallace – Birkbeck, University of London
Voltage-gates sodium channels: structure, function and disease
11.45 Professor Dr. Gary Lewin – Max Delbruck Center
Modulating force sensing channels by voltage and small molecules
12.10 Professor Nikita Gamper – Leeds University
Modulation of KV7 potassium channels by intracellular zinc
12.35 Lunch
Session 4 – Chair Professor Martin Gosling – Sussex University
14.00 Professor Thomas Jentsch – Max Delbrueck Center for Molecular Medicine
The volume regulated anion channel VRAC: structure-function and surprising roles
14.25 Professor David Sheppard – Bristol University
Cystic fibrosis: rescuing defective chloride channels with small molecules
14.50 Associate Professor Bo Hjorth Bentzen – Copenhagen University
Modulation and anti-arrhythmic potential of SK channels
15.15 Professor Raimund Dutzler – Zurich University
The mechanism of ion conduction and gating in the calcium-activated chloride channel TMEM16A
15.40 Wrap Up