Automated Patch Clamp in Cystic Fibrosis Drug Discovery

著者: Martin Gosling, Sarah Lilley, Thomas Binzer and Damian Bell

The CFTR gene encodes a cyclic AMP-regulated chloride channel, a pivotal protein responsible for epithelial chloride transport. In the lungs, chloride transport is vital in maintaining the hydration status of the airways such that mucus is runny and fluid, which fulfils a key role in protecting the airways from dangerous insults such as bacteria and other noxious particles, so it can be moved up and out of the lungs.