Cor.4U on QPatch

著者: Soren Friis, Morten Sunesen, Hervor L Olsen

Fully differentiated, cell lineages formed from human induced pluripotent stem cells (iPSC) are powerful cellular models for action potential based screening of compounds. Parallel recordings from up to 48 iPS derived cardiomyocytes are made on the QPatch HT with full analysis of action potential features including action potential duration, upstroke velocity and membrane firing potential. In this report we describe the validation of pharmacology and biophysics of iPSC from Axiogenesis on the QPatch in current clamp mode.