Cor.At cells embryonic stem cell derived cardiomyocytes on QPatch

著者: Rikke P Schrøder, Hervor L Olsen, M Knirke Jensen

Embryonic stem cell-derived cardiomyocytes have many of the phenotypic properties of authentic cardiomyocytes, and great interest has been shown in their possibilities for modeling human diseases. For drug discovery stem cell derived cardiomyocytes provide an exciting new tool for e.g. cardiac target discovery and cardiac safety studies. Axiogenesis has developed the Cor.At® cells. These cells are cardiomyocytes derived from transgenic mouse embryonic stem cells and are 99.9% pure. This report presents recordings of three essential currents; IK, ICa, and INa from the Cor.At® cells obtained with the QPatch system.