Nav1.5(Late) cardiac safety assay on QPatch

As an alternative to standard pharmacological procedures for Na_V1.5(Late) assays, we present a more reliable and accurate Na_V1.5(Late) assay on QPatch that removes the requirement for activators like veratridine and ATX-II and delivers improved cardiac safety screening reliability and cost.

• High fidelity QPatch recordings of small amplitude Na_V1.5 (Late) currents from Long QT3 syndrome mutant channels.
• Stable recordings without pharmacological activators allow more reliable drug potency assessment.
• Pharmacologically validated with sodium channel blockers with a preference for the Na_V1.5(Late).