Temperature control on Qube 384 – pharmacological dependency of hERG reference compounds

雑誌名: Sophion Application Report
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著者: R Jacobsen

To better understand how compounds function in warm-blooded animals such as humans, it is key to be able to test compound potency at physiological temperature. Our automated patch clamp systems provide real time measurement of temperature, and thus the effect of temperature change. Temperature regulation is done directly at the measurement site, and not by thermal control of the whole system. Four different compounds were tested in a dose-response format on Qube 384 at differing temperatures. All four compounds showed increased effect at elevated temperature compared to room temperature. Qube is suitable for screening compounds at temperatures from 8° C to 40° C (or 8° C above dew point).