Translational Studies on Anti-Atrial Fibrillatory Action of Oseltamivir by its in vivo and in vitro Electropharmacological Analyses


著者: Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Ai Goto, Kazuya Tsurudome, Hironori Ohshiro, Taku Izumi, Mihoko Hagiwara-Nagasawa, Koki Chiba, Ryota Nishiyama, Satomi Oyama, Yoshio Nunoi, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama


Oseltamivir can exert a powerful anti-AF action through its ideal multi-channel blocking effects on IK, ACh, IKr and INa.

Although developing a novel formulation that can reduce the effective dose against AF may be mandatory, oseltamivir would be a promising seed compound for developing efficacious and safe anti-AF drugs.