Cor.4U human iPS cell-derived cardiomyocytes on QPatch and Qube

Two new application reports with Cor.4U^® human iPS cell-derived cardiomyocytes from Ncardia on QPatch and Qube.

The hiPSC – CM provide new strategies to assess cardiotoxicity in vitro and different technologies are available to assess compound effects on cardiomyocytes.

Here we demonstrate

• High throughput and high fidelity voltage and current clamp recordings
• Presence of I_Na, I_Ca and I_Kr
• Paced and spontaneous action potentials
• We also show that the use of fluoride in the internal solution resulted in lower I_Ca and shortened action potential durations on QPatch.

See the report for QPatch (Link) and for Qube (Link)

Also, you are welcome to check out our other publications on stem cells here

Voltage- and current clamp on induced pluripotent cardiomyocytes with Qube 384

Action potentials are induced in both HL-1 mouse atrial cardiomyocytes and Axiogenesis Cor.4U iPS cell-derived cardiomyocytes.

Voltage- and current clamp on induced pluripotent cardiomyocytes with Qube 384. Action potentials are induced in both HL-1 mouse atrial cardiomyocytes and Axiogenesis Cor.4U iPS cell-derived cardiomyocytes. Qube can combine voltage clamp and current clamp in the same sweep for added experimental control. Click here to read more.