レビュー論文: 医薬品開発における高齢者向けの安全性薬理学上の課題

高齢者人口の増加が創薬に与える問題は深刻であるにもかかわらず、高齢者のための医薬品開発に対する具体的な解決策は限られています。このことは、世界中を巻き込んだ問題になる恐れがあります。

元ファイザー社の安全性薬理学の専門家であるBernard Fermini氏と弊社のDamian Bellは、創薬コミュニティに対して、高齢者層向けの医薬品の適切かつ堅牢で安全性試験を開発・実施するための議論を開始し行動するよう、その示唆に富むレビューの中で呼びかけています。

私たちは、このレビュー論文をオープンアクセスとしましたので、ぜひご一読ください。

イオンチャネルと癌

イオンチャネルは、癌の主な特徴のすべてに影響する重要なシグナル伝達タンパク質です。(上図参照)
イリノイ大学シカゴ校のSaverio Gentile教授は、この密接な関係を
「癌という名のチャネルパチー」であると明確に定義しています。

 

Sophionは、イオンチャネルモジュレーションシンポジウム、ユーザーミーティング、Webセミナーにおける研究成果のプレゼンテーションなどイオンチャネル研究の最先端にあり、世界をリードするオンコチャネロパチー研究機関を支援・協力しています。

これら講演記録へのリンクは以下の通りです。

イオンチャネルと癌

Prof. Annarosa Archangeli, ICMS 2017, ‘hERG Channels: From anti-targets to novel targets for cancer therapy’

Dr Luis Pardo, ICMS 2017, ‘Kv10.1 and the cell cycle: A two-way road’

Prof. Mustafa Djamgoz, ICMS 2019, ‘In vivo evidence for expression of voltage-gated sodium channels in cancer and potentiation of metastasis’

Prof. Saverio Gentile, User Meeting 2021, ‘Targeting potassium channels in cancer from cell signaling to precision medicine

Drug Discovery for Ion Channels XXII
– バーチャルサテライトミーティング

ソフィオンバイオサイエンスは米国生物物理学会年会サテライトミーティング “Drug Discovery for Ion Channels” を今年も共催させていただきます。今年はオンラインでの開催となります。

共催各社(Metrion Biosciences様、Fluxion様、SB Drug Discovery様、 Nanion様)と共に皆様のご参加を心よりお待ち申し上げております。

講演予定者は以下の方々です。
Irina Vetter from the University of Queensland
Andrew Jenkins – Emory University
Julie Klint – Lundbeck
John Atack – Cardiff University
Steven Griffin – University of Leeds
David Baez-Nieto – Broad Institute of MIT and Harvard

QPlate: 高パフォーマンスのAPC記録を可能にする独自のデザイン

Sophion独自のデザインであるQPlateは多くの利点を持っています。特に、100%完全な液交換、生理溶液を用いたギガシール形成、メンテナンス不要な電極が挙げられます。

今回のアプリケーションレポートでは、自動パッチクランプ装置に使用するマイクロ流路ベースの消耗品のデザインとその利点についてお伝えします。

また、QPlateの素材が生理的な溶液でどのようにしてギガオームシールを作成することが可能になるのかをご紹介しています。20 µLの溶液で100%の溶液交換が可能であることを示すデータもご覧下さい。

QPlateのデザインと性能についてのアプリケーションレポートはこちらから。

Sophionユーザーミーティング(オンライン)開催のお知らせ

ソフィオンでは2020年9月22日(火)AM11:00からPM3:30 オンラインによるユーザーミーティングの開催を予定しています。

プログラムは下記の通りです。

Zoom ウェビナーへのアクセス方法(英語版)は、こちらをクリックしてください。

11:00 AM  Sophion最新ニュース紹介
Sophion Bioscienceグローバルプロダクトマネージャー Mads Korsgaard氏
11:30 AM  Charles River Laboratories社
Biology Discovery グループリーダー Jonathan Mann氏
12:00 正午  Knopp Biosciences社 Alexander Komarov氏
12:30 PM  Astellas Institute社 Dang Dao氏
01:00 PM  イェール大学 Mark Estacion氏
01:30 PM  Xenon Pharmaceuticals社 Sam Goodchild氏
02:00 PM  Nocion Therapeutics社 Jim Ellis氏
02:30 PM  Sophion Bioscience Inc. Sung Hoon ParkによるQPatch IIデモ

各プレゼンテーションの議題は後日発表します。

本ユーザーミーティングは、Zoomウェビナーによるオンライン開催を予定しています。
参加をご希望の方は、Schyler Kingまでメールにてご連絡ください。。

ユーザーミーティングで、皆様とお会いできることを楽しみにしています。

Safety Pharmacology Society Annual Meeting 2018

We look forward to seeing you in Washington D.C. for the annual SPS meeting.

Venue:

Marriott Wardman Park
2660 Woodley Rd NW,
Washington, DC 20008

Come and see us for an ion channel talk at booth #113. Read more about the event here.

 

Japanese Safety Pharmacology Society 9th Annual Meeting

We look forward to JSPS 9th annual meeting at The University of Tokyo, Yayoi Auditorium. You can find the entire program here.

You can meet with our ion channel experts at our booth #I at the Yayoi Auditorium. We are participating in the stamp rally.

Poster Presentation

On Saturday, 10th February between 11.30 AM and 12.30 PM, Dr. Kazuya Tsurudome will present a poster titled:

Voltage and current clamp recordings from human iPS cell-derived cardiomyocytes on 384-channel automated patch-clamp system

Poster board no. 16

A list of all poster presented at JSPS can be found here.

See some of the great talks from ICMS 2017 in Cambridge

We have the pleasure of sharing with you some of the great talks from the Sophion Ion Channel Modulation Symposium which took place in Cambridge in June.

See the talks here.

Enjoy

 

Sophion Bioscience is acquired by Sophion CEO, management and investors

Sophion Bioscience has been acquired by Sophion CEO Thais T. Johansen, its management and a group of experienced investors.

Sophion was founded in 2000 as a spinoff from Neurosearch and have since the beginning been pioneering ion channel research and drug discovery. In 2004 Sophion launched the QPatch automated patch clamp solution, which still today is benchmark for advanced electrophysiology and cardiac safety in drug discovery. In 2013 Sophion Qube was launched taking automated patch clamp to the HTS space and taking automated patch clamping to a whole new level of usability. In between Sophion has continuously improved performance and capabilities and launched pioneering new features such as automated Rs compensation, automated current clamp, integrated cell preparation, etc.

Sophion was in 2011 acquired by Biolin Scientific Holding AB, a company owned by Swedish private equity firm Ratos AB.

Sophion CEO Thais Johansen states “Our new ownership structure and financial partners bring a long-term orientation and expertise in building a high-growth life science business. With this involvement, we are well-positioned to continue investing in innovation, technologies and people”.

Thais also said, “we will continue to build on the Sophion legacy with focus on quality, innovation and customer satisfaction” and continues “I am looking forward to talk to our partners over the next weeks to discuss these changes as well as discuss the many great news we have in pipeline”.

Sophion Bioscience employs approximately 60 people worldwide. It is headquartered in Copenhagen, Denmark and has subsidiaries in Boston, Tokyo and Shanghai, as well as distributors in Japan, India and Korea. Sophion has an install base of 100+ automated patch clamp systems and presence in more than 75% of the TOP20 largest Pharma companies in the world.

Sophion Bioscience, Inc. is in the building

ICMS2017 – thanks everyone for contributing

Another great Sophion Ion Channel Modulation Symposium meeting at the amazing Clare College. Knowledge sharing, socializing and presentations of new discoveries in our field from the top notch researchers from academia and pharma industry. …. and good food and beer not to mention. Great way to spend a week. ICMS2018 already in pipeline.

Safety Pharmacology Society annual meeting

Hope to see you at the annual Safety Pharmacology Meeting 2017 in Berlin. Meet us at booth #113 and speak with our ion channel experts on site.

When:  24th to 27th September

Venue: Maritim Hotel Berlin

Poster presentation (Poster #022)
Temperature effect on hERG channel pharmacology measured by using the Qube automated patch clamp system.

Abstract:

The human ether-à-go-go related gene (hERG) function is important for cardiac repolarization and inhibition of the channel can prolong the cardiac action potential, which give increased risk for ventricular arrhythmias including torsade des points (TdP). Therefore, In vitro evaluations of the compound effects is performed on the hERG channel routinely in drug development projects to detect potential arrhythmic side-effects.

Usually these compound measurements are carried out at ambient temperatures. Previously it has been shown that the potency for many compounds have been underestimated when compared to near physiological temperature tests. Therefore, a temperature controlled measuring environment is beneficial when testing compounds for the aims as mentioned here.

Until recently, the only possibility to test compound potency under voltage control conditions has been the manual patch clamp technique. Now automated patch clamp instruments with temperature control have come available making it possible to perform up to 384 parallel recordings at controlled temperatures ranging from 18°C and above.

Here we used an automated patch clamp system, Qube, to study the effect of temperature on concentration response relationships on a panel of compounds known to block the hERG channel. Qube has a temperature controlled test environment and in these studies, we show that temperature merits being taken into consideration when evaluating for hERG potency.

 

 

Neuroscience

See you at Neuroscience 2017, the world’s largest neuroscience conference for scientists and physicians devoted to understanding the brain and nervous system. You can find us at booth #823 where we look forward to meet you for an ion channel talk.

Venue:  Walter E. Washington Convention Center, Washington, DC