レビュー論文: 医薬品開発における高齢者向けの安全性薬理学上の課題

高齢者人口の増加が創薬に与える問題は深刻であるにもかかわらず、高齢者のための医薬品開発に対する具体的な解決策は限られています。このことは、世界中を巻き込んだ問題になる恐れがあります。

元ファイザー社の安全性薬理学の専門家であるBernard Fermini氏と弊社のDamian Bellは、創薬コミュニティに対して、高齢者層向けの医薬品の適切かつ堅牢で安全性試験を開発・実施するための議論を開始し行動するよう、その示唆に富むレビューの中で呼びかけています。

私たちは、このレビュー論文をオープンアクセスとしましたので、ぜひご一読ください。

イオンチャネルと癌

イオンチャネルは、癌の主な特徴のすべてに影響する重要なシグナル伝達タンパク質です。(上図参照)
イリノイ大学シカゴ校のSaverio Gentile教授は、この密接な関係を
「癌という名のチャネルパチー」であると明確に定義しています。

 

Sophionは、イオンチャネルモジュレーションシンポジウム、ユーザーミーティング、Webセミナーにおける研究成果のプレゼンテーションなどイオンチャネル研究の最先端にあり、世界をリードするオンコチャネロパチー研究機関を支援・協力しています。

これら講演記録へのリンクは以下の通りです。

イオンチャネルと癌

Prof. Annarosa Archangeli, ICMS 2017, ‘hERG Channels: From anti-targets to novel targets for cancer therapy’

Dr Luis Pardo, ICMS 2017, ‘Kv10.1 and the cell cycle: A two-way road’

Prof. Mustafa Djamgoz, ICMS 2019, ‘In vivo evidence for expression of voltage-gated sodium channels in cancer and potentiation of metastasis’

Prof. Saverio Gentile, User Meeting 2021, ‘Targeting potassium channels in cancer from cell signaling to precision medicine

BPSが主催するネットワークイベント:イオンチャンネルと自動パッチクランプ オポチュニティの世界

Biophysical Societyのイベントにご招待します:イオンチャンネルと自動パッチクランプ オポチュニティの世界

薬学界や学術研究界、バイオテクノロジー業界の中で実績を持つ熟練者の方々から、なぜイオンチャンネル分野でのキャリアを選択したのか、学術研究界から産業界への移行について、彼らの研究結果による偉大な発見、この分野の将来をどのように見ているかなどについて聞いてみましょう。

 

Sophion NAによるバーチャルユーザーミーティングの報告

さまざな分野を代表する方々から、自動パッチクランプの豊富な経験談など素晴らしいプレゼンテーションをいただきました。プレゼンテーションの後には温度制御機能に特化したQPatch II 48自動パッチクランプ装置を使用したデモンストレーションが行われました。デモンストレーションの実施にあたり遅くまでBallerupに滞在してくれたアプリケーションサイエンティストのMelanie SchuppとプロダクトマネージャーのMads Korsgaardには大変感謝いたします。

ミーティングには27機関から50名もの方々にご参加いただきました。ヨーロッパや日本など世界中からご参加いただき、大変驚きました。

また、この新たなバーチャル環境の中、魅力的な方法でそれぞれの研究内容を発表していただいたプレゼンターの方々、プログラムを円滑に運営したDaniel、WebExプラットフォームをセットアップし管理してくれたSchuyler、産業界とアカデミックの両フィールドからこのような素晴らしいプレゼングループを準備してくれたDaniel、SungそしてWeifengにも感謝しています。

次回のバーチャルミーティングに向けて私たちが準備しなければならないことは、どのようにして参加者の方々をLord Hoboビール試飲イベント会場に招待できるかです!

QRコードを読み取り、ミーティングの議題とプレゼンターのプロフィールを見ることができます。

Sophionユーザーミーティング(オンライン)開催のお知らせ

ソフィオンでは2020年9月22日(火)AM11:00からPM3:30 オンラインによるユーザーミーティングの開催を予定しています。

プログラムは下記の通りです。

Zoom ウェビナーへのアクセス方法(英語版)は、こちらをクリックしてください。

11:00 AM  Sophion最新ニュース紹介
Sophion Bioscienceグローバルプロダクトマネージャー Mads Korsgaard氏
11:30 AM  Charles River Laboratories社
Biology Discovery グループリーダー Jonathan Mann氏
12:00 正午  Knopp Biosciences社 Alexander Komarov氏
12:30 PM  Astellas Institute社 Dang Dao氏
01:00 PM  イェール大学 Mark Estacion氏
01:30 PM  Xenon Pharmaceuticals社 Sam Goodchild氏
02:00 PM  Nocion Therapeutics社 Jim Ellis氏
02:30 PM  Sophion Bioscience Inc. Sung Hoon ParkによるQPatch IIデモ

各プレゼンテーションの議題は後日発表します。

本ユーザーミーティングは、Zoomウェビナーによるオンライン開催を予定しています。
参加をご希望の方は、Schyler Kingまでメールにてご連絡ください。。

ユーザーミーティングで、皆様とお会いできることを楽しみにしています。

Japanese Safety Pharmacology Society 9th Annual Meeting

We look forward to JSPS 9th annual meeting at The University of Tokyo, Yayoi Auditorium. You can find the entire program here.

You can meet with our ion channel experts at our booth #I at the Yayoi Auditorium. We are participating in the stamp rally.

Poster Presentation

On Saturday, 10th February between 11.30 AM and 12.30 PM, Dr. Kazuya Tsurudome will present a poster titled:

Voltage and current clamp recordings from human iPS cell-derived cardiomyocytes on 384-channel automated patch-clamp system

Poster board no. 16

A list of all poster presented at JSPS can be found here.

Biophysics 2018 – here we come!

Time flies and soon BPS2018 will kick-off in San Francisco. We look forward to see you in San Francisco and hope that you will join us for the below events:

  • Satellite meeting – Friday, February 16th
  • Beer tasting and dining – Saturday, February 17th
  • Sophion Ion Channel meeting – Tuesday, February 20th
  • Poster presentation – Wednesday, February 21st

Read much more about each event here and make sure to sign up as the seats fill up quickly.

 

 

Sophion User Meeting, Boston – Save the date!

We are still working with the agenda but can, at this point, reveal that we have the pleasure of having Julie Klint, Lundbeck as one of several speakers. Julie will give a talk titled: Finding NaV1.1 activators – development and validation of a HTS suitable assay on the Qube. Also Noah Shuart from Xenon will be giving a talk.

Venue:

Sophion Bioscience, Inc.
400 Trade Center Drive, Suite 6900, Woburn, MA 01801

Agenda:

April 10th

11.30 AM        Registration and lunch buffet

01.00 PM        Presentations

02.30 PM        Coffee break

03.00 PM        Presentations

04.30 PM        Wrap up

05.30 PM        Wine tasting event onsite

 

April 11th

08.45 AM        Registration and coffee

09.30 AM        Presentations

10.30 AM        Coffee break

12.00 Noon     Lunch

02.00 PM        Wrap-up

 

Local hotels:

Hilton Boston/Woburn
2 Forbes Road, Woburn, MA
Phone: +1 781-932-0999

Crowne Plaza Boston/Woburn
15 Middlesex Canal Park Drive, Woburn, MA
Phone: +1 781-935-8760

Comfort Inn Boston/Woburn
14 Hill St, Woburn, MA 01801
Phone: +1 781-933-5363

 

ICMS 2018

We are thrilled to announce the dates for next years’ Sophion Ion Channel Modulation Symposium and look forward to seeing so many ion channel professionals again next June.

The venue is the same as the previous two years: Clare College in Cambridge and the dates are 20th and 21st June, 2018.

See much more information about this meeting here.

Biophysical Society 62nd Annual Meeting

We look forward to Biophysics 2018 where we will be doing a lot of activities:

First of all you can meet with our ion channel experts at our booth #518 at the Moscone Center.

Satellite Meeting

Friday, 16th February Sophion will be hosting the annually recurring satellite meeting, Drug Discovery for Ion Channels. 

See the agenda for the meeting here and make sure to sign up as the spaces are limited. 

Beer Tasting & Dinner

Saturday, 17th February we have the pleasure of inviting you to an informal evening of beer tasting, good food and great networking at the Bartlett Hall in San Francisco.

Make sure to sign up for this event here. Limited number of seats so be quick.

Ion Channel Mini Symposium

Tuesday, 20th February we will be having a short meeting at the conference center with the presentation title: Drug discovery and electrophysiological characterization using automated patch clamp (QPatch).

Venue: Room 6, Moscone Center, San Francisco – sign up here for the meeting:

10:30 – 11:00
Dr Damian Bell, Iontas Ltd.
Efficient ion channel cell line generation using MaxCyte electroporation and QPatch validation

11:00 – 11:30
Dr Daniel Sauter, Application Scientist, Sophion Bioscience A/S
Induced pluripotent stem cell-derived cardiomyocytes (Cor.4U) characterized on an automated planar patch clamp set up (QPatch HT)

11:30 – 12:00
Dr Alan Wickenden, Scientific Director & Fellow, Molecular & Cellular Pharmacology, Janssen R&D, L.L.C
NaViGATING the long and winding road to new analgesics: Discovery of potent, selective, closed-state peptide Nav1.7 blockers

Refreshments will be served.

Poster Presentation

Wednesday, 21st February between 10.30 AM and 11.30 AM, Dr Daniel Sauter will present a poster titled:

Induced pluripotent stem cell-derived cardiomyocytes (Cor.4U) characterized on an automated planar patch clamp setup (QPatch HT)

Poster board no. B301

See some of the great talks from ICMS 2017 in Cambridge

We have the pleasure of sharing with you some of the great talks from the Sophion Ion Channel Modulation Symposium which took place in Cambridge in June.

See the talks here.

Enjoy

 

Qube version “Duck” is now available

Enjoy current clamp combined with voltage clamp in the same sweep and on all 384 sites to make you results very tight. Cool or heat at the recording site to investigate the temperature sensitivity of the pharmacology you are interested in. Load Qube with stock solutions and let it dilute it to the final test concentration only seconds before adding it to the cell. This and many more updates is the latest results of the constant development Sophion is putting into our products based on inputs from our customers.

Sophion Bioscience is acquired by Sophion CEO, management and investors

Sophion Bioscience has been acquired by Sophion CEO Thais T. Johansen, its management and a group of experienced investors.

Sophion was founded in 2000 as a spinoff from Neurosearch and have since the beginning been pioneering ion channel research and drug discovery. In 2004 Sophion launched the QPatch automated patch clamp solution, which still today is benchmark for advanced electrophysiology and cardiac safety in drug discovery. In 2013 Sophion Qube was launched taking automated patch clamp to the HTS space and taking automated patch clamping to a whole new level of usability. In between Sophion has continuously improved performance and capabilities and launched pioneering new features such as automated Rs compensation, automated current clamp, integrated cell preparation, etc.

Sophion was in 2011 acquired by Biolin Scientific Holding AB, a company owned by Swedish private equity firm Ratos AB.

Sophion CEO Thais Johansen states “Our new ownership structure and financial partners bring a long-term orientation and expertise in building a high-growth life science business. With this involvement, we are well-positioned to continue investing in innovation, technologies and people”.

Thais also said, “we will continue to build on the Sophion legacy with focus on quality, innovation and customer satisfaction” and continues “I am looking forward to talk to our partners over the next weeks to discuss these changes as well as discuss the many great news we have in pipeline”.

Sophion Bioscience employs approximately 60 people worldwide. It is headquartered in Copenhagen, Denmark and has subsidiaries in Boston, Tokyo and Shanghai, as well as distributors in Japan, India and Korea. Sophion has an install base of 100+ automated patch clamp systems and presence in more than 75% of the TOP20 largest Pharma companies in the world.

Sophion Bioscience, Inc. is in the building

ICMS2017 – thanks everyone for contributing

Another great Sophion Ion Channel Modulation Symposium meeting at the amazing Clare College. Knowledge sharing, socializing and presentations of new discoveries in our field from the top notch researchers from academia and pharma industry. …. and good food and beer not to mention. Great way to spend a week. ICMS2018 already in pipeline.

Safety Pharmacology Society annual meeting

Hope to see you at the annual Safety Pharmacology Meeting 2017 in Berlin. Meet us at booth #113 and speak with our ion channel experts on site.

When:  24th to 27th September

Venue: Maritim Hotel Berlin

Poster presentation (Poster #022)
Temperature effect on hERG channel pharmacology measured by using the Qube automated patch clamp system.

Abstract:

The human ether-à-go-go related gene (hERG) function is important for cardiac repolarization and inhibition of the channel can prolong the cardiac action potential, which give increased risk for ventricular arrhythmias including torsade des points (TdP). Therefore, In vitro evaluations of the compound effects is performed on the hERG channel routinely in drug development projects to detect potential arrhythmic side-effects.

Usually these compound measurements are carried out at ambient temperatures. Previously it has been shown that the potency for many compounds have been underestimated when compared to near physiological temperature tests. Therefore, a temperature controlled measuring environment is beneficial when testing compounds for the aims as mentioned here.

Until recently, the only possibility to test compound potency under voltage control conditions has been the manual patch clamp technique. Now automated patch clamp instruments with temperature control have come available making it possible to perform up to 384 parallel recordings at controlled temperatures ranging from 18°C and above.

Here we used an automated patch clamp system, Qube, to study the effect of temperature on concentration response relationships on a panel of compounds known to block the hERG channel. Qube has a temperature controlled test environment and in these studies, we show that temperature merits being taken into consideration when evaluating for hERG potency.

 

 

Neuroscience

See you at Neuroscience 2017, the world’s largest neuroscience conference for scientists and physicians devoted to understanding the brain and nervous system. You can find us at booth #823 where we look forward to meet you for an ion channel talk.

Venue:  Walter E. Washington Convention Center, Washington, DC