Controlling the temperature of your experiment standardizes the testing environment and reduces outside influences. Both QPatch and Qube now feature the ability to control the temperature enabling experiments to be performed at physiological temperatures.
Due to the risk of the fatal arrhythmia Torsade de Pointes, all drug candidates are tested for their potential modulation of the cardiac ion channel hERG. Some hERG-blockers are more potent at physiological temperatures than at lower temperatures, and their potency may, therefore, be underestimated when tested at room temperature.
The QPatch temperature box, QT, uses compressed air and airflow to heat up the QPlate to temperatures from room temperature to 40°C. The Qube temperature box uses water to control the temperature at the recording chamber. Applications include better elucidation of ion channel kinetics and toxicity data that are more closely aligned to the physiological reality.
Features & Benefits:
- High performance patch clamp experiments at temperatures from room temperature up to 40°C
- Dedicated action potential and frequency analysis package
- Applicable for primary cells, stem cells, neurons and immortalized cells
- Upgrade package available for all systems