Sophionセミナー開催のお知らせ

Agendaを公開しました。

Qubeによって解明された作用メカニズム

Sophisticated structure activity relationship revealed

創薬研究向けに開発されたQube

Let it run during night

New papers, posters and reports (Q3 2018)

We have been busy and so have our partners. 11 new peer reviewed publications, 7 new posters, 5 new application reports from the last couple of months. Enjoy.

新機種QPatch IIの発表について

QPatchは2000年代の初めより、安全性薬理および創薬スクリーニングの研究フィールドにおいて、イオンチャネル評価系のベンチマーク的なオートパッチクランプシステムして、日本国内でも多くユーザー様にご愛用頂いて参りました。 今回発表いたしますQPatch IIでは、QPatchで高く評価されてきたデータの品質を維持しつつ、実際の運用における作業効率と使い勝手の良さが著しく向上しております。 9月30日(日)より米国ワシントンDCにて開催されるSPS(安全性薬理学会)では、Sophionのブース(113番)にてQPatch IIの実機の展示を行い、日本からのご参加の皆さまには日本語でこの新機種の発表会を行います。SPSへご参加なさる方は、是非Sophionのブースにお越し頂くとともに、発表会へもご参加下さい。なお、発表会の日程と会場はブースにてお知らせいたします。 また10月19日(金)には、東京にてSophionセミナーが開催され、そちらの会場でもQPatch IIの実機展示を行います。本セミナーでも新機種の機能とバリデーションデータ等を紹介いたしますので、皆さまのお越しをお待ち申し上げております。お申し込みはこちらからお手続きをください。セミナーの概要はこちらになります。 なお、年内には当社の国内ラボにもQPatch IIが設置される予定でございます。新機種のデモをご希望のお客様は、info@sophion.co.jpまでメールにてご予約のリクエストをお送りください。後ほど担当者よりご連絡差し上げます。  

Sophion co-organized channelopathy symposium in China

Another great symposium, this time in China. It was a pleasure for us at Sophion to co-organize this event and we were happy to see the large attendance from engaged researchers.

ウェブサイトリニューアルのお知らせ

平素は格別のお引き立てを賜り、誠にありがとうございます。 この度、当社のウェブサイトを全面リニューアルいたしました。 今回は、日本語にて当社のリソースライブラリをご覧頂けるように操作環境を改善いたしました。当社の製品や技術に関連した文献、アプリケーションレポート、学会発表ポスター、そしてイオンチャネル研究分野における最新情報を、より簡便にご利用いただければと考えております。 当社の新しいウエブサイトにてご提供する情報が、皆さまのご研究の一助となれば幸いです。 今後ともどうぞよろしくお願い申し上げます。

Super-short ligand exposure time on Qube Opto 384

Optogenetics combined with microfluidic channels is a powerful combination when a short ligand exposure time is needed. Here we have tested both instantaneous washout and washout after 500 milliseconds to achieve ultrashort GABA responses on the Qube Opto 384.

Updated privacy policy

Here we go again… another statement on privacy. We will continue to handle your personal information with integrity and respect

hCav1.2 recordings using QPatch

A reproducible QPatch assay with high success rates for biophysical and pharmacological studies of the Cav1.2 channel

ICMS 2018 coming up shortly…..

Counting down to Sophion Ion Channel Modulation Symposium 2018

GABAA pharmacology on cell lines and primary astrocytes on QPatch

Pharmacological manipulation of the GABA ion channel has a large potential. The central role of GABA in the nervous system is underscored by the devastating consequences of pathophysiological changes in GABA signalling. Conversely, manipulation of GABA receptors can offer relief of a large group of neurological and psychiatric disorders.

Light activated rubi-GABA on Qube Opto 384

GABA mediated currents elicited by optical uncaging in both a concentration and light dependant fashion.

Cor.4U human iPS cell-derived cardiomyocytes on QPatch and Qube

QPatch studies on voltage- and current clamp recordings on Cor.4U human iPS cell-derived cardiomyocytes

How easy is it to use Qube?

Two days training is enough

Qube Opto 384 – for optical stimulation of ion channels or compounds.

Patch clamp and optogenetics – Discover the Qube with 384 integrated and adjustable LEDs for advanced optogenetic measurements

High throughput screening on Nav1.1 using Qube

Mode-of-action pharmacology in real unattended high-fidelity HTS

Welcome to our new field service engineer, Thomas Byrne

Please welcome Thomas Byrne to the North American team as our new Technical Service Engineer based in Boston!

Virtual Qube – Increase value from your CRO data

Get the power to analyze the Qube data generated by your external partner

hCav1.2 recordings on Qube 384 using step, train and CiPA protocols

A reproducible high-throughput assay with high success rates for biophysical and pharmacological studies of the Cav1.2 channel

Biophysics 2018 – here we come!

Drop by our booth #518 and meet with our experts to discuss your ion channel needs.

2017 in brief

For Sophion it has been a year with many changes, a lot of news and countless achievements. It has also, by far, been the best year in the history of Sophion Bioscience……

Happy New Year

Wish you a successful and happy New Year

Registration for ICMS2018 is now open

The places fill up quickly so please make sure to register ASAP!

Santa’s little helpers…..?

More systems ready to ship to customers

Fast desensitizing ion channels recorded on Qube 384

Short ligand exposure time (0.8 s) counteracts channel desensitization on nAChRa1

Five new QPatch publications from top pharma companies

It is great to see the current high publication activity with our QPatch system worldwide.

Sophion user meeting in our new facilities in Japan

Double up on space in Sophion Japan

High throughput screening for mode-of-action on Nav1.4

Qube, an ideal tool for profiling large compound libraries on voltage-gated sodium channels.

ICMS 2018

Mark your calendar for the Sophion Ion Channel Modulation Symposium 2018

Eight new QPatch publications, two of them in Nature.com

A lot of new peer reviewed publications have seen the light over the summer. Here is some selected new publications. For more interesting publilcations on QPatch and Qube you can always search our publication database

Poster presented at SPS in Berlin in September on temperature effect using Qube

Temperature effect on hERG channel pharmacology measured using the Qube automated patch clamp system

New faces at Sophion

We are staffing up again. We have hired two new application specialists to meet the increasing demand of new application development and customer support. Meet Dr. Kadla Røskva Rosholm and Dr. Kim Boddum at customer sites, demos or conferences.

Qube 384 recordings with very short exposure time of ligand

Some like it slow, some like it fast. A Qube user wanted faster washout of activator in ligand gated experiments and contacted their application scientist.

Tecan publishing article about QPatch

Article from Tecan about Sophion and QPatch: OEM instrument design offers automated patch clamping solution

See some of the great talks from ICMS 2017 in Cambridge

Did you miss the Sophion Ion Channel Modulation Symposium in Cambridge in June?

Qube version “Duck” is now available

Enjoy current clamp combined with voltage clamp in the same sweep and on all 384 sites to make you results very tight. Cool or heat at the recording site to investigate the temperature sensitivity of the pharmacology you are interested in. Load Qube with stock solutions and let it dilute it to the final test …

Temperature control on Qube 384 – pharmacological dependency of hERG reference compounds

Significant temperature sensitivity of hERG pharmacology revealed with Qube 384 temperature controlled recordings

Sophion Bioscience is acquired by Sophion CEO, management and investors

Sophion Bioscience has been acquired by Sophion CEO Thais T. Johansen, its management and a group of experienced investors.

Sophion Bioscience, Inc. is in the building

Sophion Bioscience, Inc. are now all settled their news office in Boston. 

ICMS2017 – thanks everyone for contributing

Another great Sophion Ion Channel Modulation Symposium meeting at the amazing Clare College. Knowledge sharing, socializing and presentations of new discoveries in our field from the top notch researchers from academia and pharma industry. …. and good food and beer not to mention. Great way to spend a week. ICMS2018 already in pipeline.

Ph.D. course at Sophion Denmark

PhD summer school on cardiac electrophysiology with 30 students from across Europe

New paper on KCa2.X (SK) on QPatch

Inhibitory effect of some established Atrial Fibrillation drugs on SK channels

Interested in CFTR? ….or traditional Chinese/Japanese medicine?

Traditional Japanese Kampo medicine compound improves opioid-induced constipation in rats by activating cystic fibrosis transmembrane conductance regulator.

Ion channel blocking antibodies

Knotbodies as therapeutic agents – concentration-dependent inhibition of Kv1.3 and ASIC1a currents demonstrated using QPatch automated patch clamp.

Internal solution exchange on Qube 384 – New application report

Internal addition of compounds targeting the chloride channel CIC-1. A robust assay with good pharmacology and high Z-score

Sophion in the US is moving to Boston

New Sophion offices and laboratory in Boston

New Nature paper on QPatch and neuronal stem cells

New QPatch paper in Nature/Scientific data proves the feasibility of automated electrophysiological characterization of neuronal cells

Ion Channel Modulation Symposium 2017 – see the agenda

We are working with the final details for this years’ agenda and we are very proud of the line up. Again this year we have a good programme with excellent speakers and interesting topics. You can see the agenda here.    

Voltage- and current clamp on induced pluripotent cardiomyocytes with Qube 384

Action potentials are induced in both HL-1 mouse atrial cardiomyocytes and Axiogenesis Cor.4U iPS cell-derived cardiomyocytes.

Cav1.2 on Qube 384

Stable Cav1.2 recordings on Qube 384 – a robust assay with high success rate and reliable pharmacology