12月7日にBrisbane Pain Research Symposiumが開催されます

Sophionは12月7日にオーストラリアのブリスベンで開かれる疼痛研究シンポジウム(Brisbane Pain Research Symposium)を支援しています。このシンポジウムの目的は、痛みの研究と治療を進めるための科学的議論、共同研究、および継続的な取り組みを活性化することです。皆様のご参加をお待ちしております。 詳細はこちらをご覧ください。

GABA受容体 -初代培養細胞および安定発現細胞株を用いた電気生理学および光薬理学的ハイスループットスクリーニング

  GABAは、肉体と精神の機能の多くを制御する中枢神経系における重要な神経伝達物質であり、不安障害、不眠症、うつ病などの複数の健康面の課題に関与しています。 このポスターでは、QPatchおよびQube 384を用いてGABAARによる薬理学的調節ついて示しています。この研究では、海馬星状膠細胞の初代培養におけるGABAAR不均一集団の特性解析およびGABAARクローンであるɑ5β3γ2サブタイプの評価を行っています。 この結果は、QubeおよびQPatchにおけるGABAARを標的とする薬剤スクリーニングの実行可能性を実証する一方、ハイスループットの薬理実験で実施しうるアプリケーションの可能性としての光薬理学を紹介しています。 こちらからポスターを参照してください。

SPS 2018にて発表されたQubeおよびQPatch関連ポスター

QubeまたはQPatchから得られた結果を載せた心臓安全性評価に関する6題のポスターが、Washington DC で開催されたSPSで発表されました

Society for Neuroscience 2018とNcardia Applications Workshop 2018で発表したポスターを公表しました

Society for Neuroscience 2018とNcardia Applications Workshop 2018で発表したポスターを公表しました

QPatchを用いたCiPA推奨のMilnes hERG動態アッセイ

私たちはメトリオンバイオサインスの協力のもと、非常に困難とされるMilnesの hERG心臓安全性試験をQpatchで実施しました。

患者由来および正常hIPS運動ニューロンにおけるQubeおよびQPatchによる評価

脊髄性筋萎縮症(SMA)または筋萎縮性側索硬化症(ALS)患者由来のヒトiPS細胞を用いて電気生理学的特性を評価し,それらの結果を対照の細胞株と比較しました.

韓国生理学会70回大会にてブースを展示しました

2018年10月25日から27日まで韓国の江原道原州市で開催されたThe 70th Annual Meeting of the Korean Physiological Societyにおいて、Sophionとして初めて韓国内でブース展示を行いました。 学会のウェブサイトへのリンクはこちらです。 SophionはSure Medical. Inc. を韓国における代理店として迎え、今後もアジア太平洋地域においてQPatch IIやQubeの積極的な普及に努めます。

Come and see our brand new QPatch II

We look forward to greet you at our booth #1933 at the Neuroscience annual meeting in San Diego. Make sure to ask one of our ion channel experts for a demo of QPatch II. Read more about our activities at the conference here. See you in San Diego in November.  

31 new Publications and Reports from Q3

Many new and interesting papers are available. Enjoy your reading

Sophion Seminar in Japan

2018年のSophionセミナーも 好評のうちに終了することができました.
ご参加頂いた皆様には厚くお礼申し上げます.

Sophionセミナー開催のお知らせ

Agendaを公開しました。

Qubeによって解明された作用メカニズム

Sophisticated structure activity relationship revealed

創薬研究向けに開発されたQube

Let it run during night

New papers, posters and reports (Q3 2018)

We have been busy and so have our partners. 11 new peer reviewed publications, 7 new posters, 5 new application reports from the last couple of months. Enjoy.

新機種QPatch IIの発表について

QPatchは2000年代の初めより、安全性薬理および創薬スクリーニングの研究フィールドにおいて、イオンチャネル評価系のベンチマーク的なオートパッチクランプシステムして、日本国内でも多くユーザー様にご愛用頂いて参りました。
今回発表いたしますQPatch IIでは、QPatchで高く評価されてきたデータの品質を維持しつつ、実際の運用における作業効率と使い勝手の良さが著しく向上しております。10月19日(金)には、東京都内で開催されるSophionセミナーにてQPatch IIの実機展示を行います。

Sophion co-organized channelopathy symposium in China

北京大学にて「チャネル病と創薬に関する国際シンポジウム – 薬物標的としてのイオンチャンネル」
というタイトルでチャネロパチーミーティングを共催しました.ソフィオンではこのイベントを中国で共催し,多くの研究者の交流に寄与することができたことを大変嬉しく存じます.

ウェブサイトリニューアルのお知らせ

平素は格別のお引き立てを賜り、誠にありがとうございます。 この度、当社のウェブサイトを全面リニューアルいたしました。 今回は、日本語にて当社のリソースライブラリをご覧頂けるように操作環境を改善いたしました。当社の製品や技術に関連した文献、アプリケーションレポート、学会発表ポスター、そしてイオンチャネル研究分野における最新情報を、より簡便にご利用いただければと考えております。 当社の新しいウエブサイトにてご提供する情報が、皆さまのご研究の一助となれば幸いです。 今後ともどうぞよろしくお願い申し上げます。

Super-short ligand exposure time on Qube Opto 384

Optogenetics combined with microfluidic channels is a powerful combination when a short ligand exposure time is needed. Here we have tested both instantaneous washout and washout after 500 milliseconds to achieve ultrashort GABA responses on the Qube Opto 384.

Updated privacy policy

Here we go again… another statement on privacy. We will continue to handle your personal information with integrity and respect

hCav1.2 recordings using QPatch

A reproducible QPatch assay with high success rates for biophysical and pharmacological studies of the Cav1.2 channel

ICMS 2018 coming up shortly…..

Counting down to Sophion Ion Channel Modulation Symposium 2018

GABAA pharmacology on cell lines and primary astrocytes on QPatch

Pharmacological manipulation of the GABA ion channel has a large potential. The central role of GABA in the nervous system is underscored by the devastating consequences of pathophysiological changes in GABA signalling. Conversely, manipulation of GABA receptors can offer relief of a large group of neurological and psychiatric disorders.

Light activated rubi-GABA on Qube Opto 384

GABA mediated currents elicited by optical uncaging in both a concentration and light dependant fashion.

Cor.4U human iPS cell-derived cardiomyocytes on QPatch and Qube

QPatch studies on voltage- and current clamp recordings on Cor.4U human iPS cell-derived cardiomyocytes

How easy is it to use Qube?

Two days training is enough

Qube Opto 384 – for optical stimulation of ion channels or compounds.

Patch clamp and optogenetics – Discover the Qube with 384 integrated and adjustable LEDs for advanced optogenetic measurements

High throughput screening on Nav1.1 using Qube

Mode-of-action pharmacology in real unattended high-fidelity HTS

Welcome to our new field service engineer, Thomas Byrne

Please welcome Thomas Byrne to the North American team as our new Technical Service Engineer based in Boston!

Virtual Qube – Increase value from your CRO data

Get the power to analyze the Qube data generated by your external partner

hCav1.2 recordings on Qube 384 using step, train and CiPA protocols

A reproducible high-throughput assay with high success rates for biophysical and pharmacological studies of the Cav1.2 channel

Biophysics 2018 – here we come!

Drop by our booth #518 and meet with our experts to discuss your ion channel needs.

2017 in brief

For Sophion it has been a year with many changes, a lot of news and countless achievements. It has also, by far, been the best year in the history of Sophion Bioscience……

Happy New Year

Wish you a successful and happy New Year

Registration for ICMS2018 is now open

The places fill up quickly so please make sure to register ASAP!

Santa’s little helpers…..?

More systems ready to ship to customers

Fast desensitizing ion channels recorded on Qube 384

Short ligand exposure time (0.8 s) counteracts channel desensitization on nAChRa1

Five new QPatch publications from top pharma companies

It is great to see the current high publication activity with our QPatch system worldwide.

Sophion user meeting in our new facilities in Japan

Double up on space in Sophion Japan

High throughput screening for mode-of-action on Nav1.4

Qube, an ideal tool for profiling large compound libraries on voltage-gated sodium channels.

ICMS 2018

Mark your calendar for the Sophion Ion Channel Modulation Symposium 2018

Eight new QPatch publications, two of them in Nature.com

A lot of new peer reviewed publications have seen the light over the summer. Here is some selected new publications. For more interesting publilcations on QPatch and Qube you can always search our publication database

Poster presented at SPS in Berlin in September on temperature effect using Qube

Temperature effect on hERG channel pharmacology measured using the Qube automated patch clamp system

New faces at Sophion

We are staffing up again. We have hired two new application specialists to meet the increasing demand of new application development and customer support. Meet Dr. Kadla Røskva Rosholm and Dr. Kim Boddum at customer sites, demos or conferences.

Qube 384 recordings with very short exposure time of ligand

Some like it slow, some like it fast. A Qube user wanted faster washout of activator in ligand gated experiments and contacted their application scientist.

Tecan publishing article about QPatch

Article from Tecan about Sophion and QPatch: OEM instrument design offers automated patch clamping solution

See some of the great talks from ICMS 2017 in Cambridge

Did you miss the Sophion Ion Channel Modulation Symposium in Cambridge in June?

Qube version “Duck” is now available

Enjoy current clamp combined with voltage clamp in the same sweep and on all 384 sites to make you results very tight. Cool or heat at the recording site to investigate the temperature sensitivity of the pharmacology you are interested in. Load Qube with stock solutions and let it dilute it to the final test …

Temperature control on Qube 384 – pharmacological dependency of hERG reference compounds

Significant temperature sensitivity of hERG pharmacology revealed with Qube 384 temperature controlled recordings

Sophion Bioscience is acquired by Sophion CEO, management and investors

Sophion Bioscience has been acquired by Sophion CEO Thais T. Johansen, its management and a group of experienced investors.

Sophion Bioscience, Inc. is in the building

Sophion Bioscience, Inc. are now all settled their news office in Boston. 

ICMS2017 – thanks everyone for contributing

Another great Sophion Ion Channel Modulation Symposium meeting at the amazing Clare College. Knowledge sharing, socializing and presentations of new discoveries in our field from the top notch researchers from academia and pharma industry. …. and good food and beer not to mention. Great way to spend a week. ICMS2018 already in pipeline.

Ph.D. course at Sophion Denmark

PhD summer school on cardiac electrophysiology with 30 students from across Europe

New paper on KCa2.X (SK) on QPatch

Inhibitory effect of some established Atrial Fibrillation drugs on SK channels

Interested in CFTR? ….or traditional Chinese/Japanese medicine?

Traditional Japanese Kampo medicine compound improves opioid-induced constipation in rats by activating cystic fibrosis transmembrane conductance regulator.

Ion channel blocking antibodies

Knotbodies as therapeutic agents – concentration-dependent inhibition of Kv1.3 and ASIC1a currents demonstrated using QPatch automated patch clamp.

Internal solution exchange on Qube 384 – New application report

Internal addition of compounds targeting the chloride channel CIC-1. A robust assay with good pharmacology and high Z-score

Sophion in the US is moving to Boston

New Sophion offices and laboratory in Boston

New Nature paper on QPatch and neuronal stem cells

New QPatch paper in Nature/Scientific data proves the feasibility of automated electrophysiological characterization of neuronal cells

Ion Channel Modulation Symposium 2017 – see the agenda

We are working with the final details for this years’ agenda and we are very proud of the line up. Again this year we have a good programme with excellent speakers and interesting topics. You can see the agenda here.    

Voltage- and current clamp on induced pluripotent cardiomyocytes with Qube 384

Action potentials are induced in both HL-1 mouse atrial cardiomyocytes and Axiogenesis Cor.4U iPS cell-derived cardiomyocytes.

Cav1.2 on Qube 384

Stable Cav1.2 recordings on Qube 384 – a robust assay with high success rate and reliable pharmacology